<?xml version="1.0" encoding="us-ascii" standalone="yes"?>
<!--Created by EdgarAgents, Powered by IRIS Carbon, Unique Code 62ec289ae172761550228250, Generated At Thu, 04 Aug 2022 20:15:03 GMT-->
<link:linkbase xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xl="http://www.xbrl.org/2003/XLink" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xbrli="http://www.xbrl.org/2003/instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureRestructuringAndOtherRelatedChargesSummaryOfRestructuringAndOtherRelatedChargesDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureRestructuringAndOtherRelatedChargesSummaryOfRestructuringAndOtherRelatedChargesDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_StatementCondensedConsolidatedStatementsOfComprehensiveLossUnaudited" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_StatementCondensedConsolidatedStatementsOfComprehensiveLossUnaudited" />
  <link:roleRef roleURI="http://electrocore.com/role/InventoriesInventoriesDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#InventoriesInventoriesDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/CondensedConsolidatedBalanceSheetsUnaudited" xlink:type="simple" xlink:href="ecor-20220630.xsd#CondensedConsolidatedBalanceSheetsUnaudited" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureLeasesFutureMinimumLeasePaymentsUnderNonCancellableOperatingLeasesDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureLeasesFutureMinimumLeasePaymentsUnderNonCancellableOperatingLeasesDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_StatementCondensedConsolidatedStatementsOfCashFlowsUnaudited" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_StatementCondensedConsolidatedStatementsOfCashFlowsUnaudited" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureCashCashEquivalentsAndMarketableSecuritiesSummaryOfCashCashEquivalentsAndMarketableSecuritiesDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureCashCashEquivalentsAndMarketableSecuritiesSummaryOfCashCashEquivalentsAndMarketableSecuritiesDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureLeasesSupplementalBalanceSheetInformationForOperatingLeasesDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureLeasesSupplementalBalanceSheetInformationForOperatingLeasesDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_StatementCondensedConsolidatedStatementsOfOperationsUnaudited" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_StatementCondensedConsolidatedStatementsOfOperationsUnaudited" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureAccruedExpensesAndOtherCurrentLiabilitiesScheduleOfAccruedExpensesDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureAccruedExpensesAndOtherCurrentLiabilitiesScheduleOfAccruedExpensesDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DocumentDocumentAndEntityInformation" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DocumentDocumentAndEntityInformation" />
  <link:roleRef roleURI="http://electrocore.com/role/CondensedConsolidatedBalanceSheetsUnauditedParenthetical" xlink:type="simple" xlink:href="ecor-20220630.xsd#CondensedConsolidatedBalanceSheetsUnauditedParenthetical" />
  <link:roleRef roleURI="http://electrocore.com/role/CondensedConsolidatedStatementsofEquity" xlink:type="simple" xlink:href="ecor-20220630.xsd#CondensedConsolidatedStatementsofEquity" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureTheCompany" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureTheCompany" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureSummaryOfSignificantAccountingPolicies" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureSummaryOfSignificantAccountingPolicies" />
  <link:roleRef roleURI="http://electrocore.com/role/SignificantRisksandUncertainties" xlink:type="simple" xlink:href="ecor-20220630.xsd#SignificantRisksandUncertainties" />
  <link:roleRef roleURI="http://electrocore.com/role/Revenue" xlink:type="simple" xlink:href="ecor-20220630.xsd#Revenue" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureInventories" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureInventories" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureLeases" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureLeases" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureAccruedExpensesAndOtherCurrentLiabilities" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureAccruedExpensesAndOtherCurrentLiabilities" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureNetLossPerShare" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureNetLossPerShare" />
  <link:roleRef roleURI="http://electrocore.com/role/Incometaxes" xlink:type="simple" xlink:href="ecor-20220630.xsd#Incometaxes" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureStockBasedCompensation" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureStockBasedCompensation" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureCommitmentsAndContingencies" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureCommitmentsAndContingencies" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureSubsequentEvents" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureSubsequentEvents" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureSummaryOfSignificantAccountingPoliciesPolicies" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureSummaryOfSignificantAccountingPoliciesPolicies" />
  <link:roleRef roleURI="http://electrocore.com/role/SummaryofSignificantAccountingPoliciesTables" xlink:type="simple" xlink:href="ecor-20220630.xsd#SummaryofSignificantAccountingPoliciesTables" />
  <link:roleRef roleURI="http://electrocore.com/role/SignificantRisksandUncertaintiesTables" xlink:type="simple" xlink:href="ecor-20220630.xsd#SignificantRisksandUncertaintiesTables" />
  <link:roleRef roleURI="http://electrocore.com/role/RevenueTables" xlink:type="simple" xlink:href="ecor-20220630.xsd#RevenueTables" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureInventoriesTables" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureInventoriesTables" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureLeasesTables" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureLeasesTables" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureAccruedExpensesAndOtherCurrentLiabilitiesTables" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureAccruedExpensesAndOtherCurrentLiabilitiesTables" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureNetLossPerShareTables" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureNetLossPerShareTables" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureStockBasedCompensationTables" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureStockBasedCompensationTables" />
  <link:roleRef roleURI="http://electrocore.com/role/TheCompanyDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#TheCompanyDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/SummaryofSignificantAccountingPoliciesDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#SummaryofSignificantAccountingPoliciesDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/SummaryofSignificantAccountingPoliciesScheduleofcashequivalentsandrestrictedcashDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#SummaryofSignificantAccountingPoliciesScheduleofcashequivalentsandrestrictedcashDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/SignificantRisksandUncertaintiesAdditionalInformationDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#SignificantRisksandUncertaintiesAdditionalInformationDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/SignificantRisksandUncertaintiesScheduleofcompanysnetsalesDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#SignificantRisksandUncertaintiesScheduleofcompanysnetsalesDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/SignificantRisksandUncertaintiesScheduleoffurtherrevenueconcentrationwithintheVADoDDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#SignificantRisksandUncertaintiesScheduleoffurtherrevenueconcentrationwithintheVADoDDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/RevenueSummaryofNetSalesDisaggregatedbyGeographicAreaDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#RevenueSummaryofNetSalesDisaggregatedbyGeographicAreaDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/RevenueAdditionalInformationDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#RevenueAdditionalInformationDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/InventoriesAdditionalInformationDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#InventoriesAdditionalInformationDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureLeasesSupplementalStatementOfCashFlowsInformationForOperatingLeasesDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureLeasesSupplementalStatementOfCashFlowsInformationForOperatingLeasesDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureLeasesFutureMinimumLeasePaymentsUnderNonCancellableOperatingLeasesDetails2" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureLeasesFutureMinimumLeasePaymentsUnderNonCancellableOperatingLeasesDetails2" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureLeasesAdditionalInformationDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureLeasesAdditionalInformationDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/AccruedExpensesandOtherCurrentLiabilitiesDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#AccruedExpensesandOtherCurrentLiabilitiesDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/NetLossPerShareAdditionalInformationDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#NetLossPerShareAdditionalInformationDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureNetLossPerShareScheduleOfCommonStockEquivalentsExcludedFromComputationOfDilutedLossPerShareDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureNetLossPerShareScheduleOfCommonStockEquivalentsExcludedFromComputationOfDilutedLossPerShareDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/NetLossPerShareScheduleofstockpurchasewarrantsoutstandingDetails2" xlink:type="simple" xlink:href="ecor-20220630.xsd#NetLossPerShareScheduleofstockpurchasewarrantsoutstandingDetails2" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureIncomeTaxesAdditionalInformationDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureIncomeTaxesAdditionalInformationDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureStockBasedCompensationAdditionalInformationDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureStockBasedCompensationAdditionalInformationDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureStockBasedCompensationSummaryOfActivityRelatedToStockOptionsDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureStockBasedCompensationSummaryOfActivityRelatedToStockOptionsDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureStockBasedCompensationSummaryOfActivityRelatedToRestrictedStockAwardsGrantedDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureStockBasedCompensationSummaryOfActivityRelatedToRestrictedStockAwardsGrantedDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureStockBasedCompensationSummaryOfActivityRelatedToRestrictedStockAndDeferredStockUnitsGrantedDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureStockBasedCompensationSummaryOfActivityRelatedToRestrictedStockAndDeferredStockUnitsGrantedDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureStockBasedCompensationScheduleOfRecognizedStockCompensationForEquityAwardsDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureStockBasedCompensationScheduleOfRecognizedStockCompensationForEquityAwardsDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureStockBasedCompensationSummaryOfWeightedAverageAssumptionsUsedInValuingPlansDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureStockBasedCompensationSummaryOfWeightedAverageAssumptionsUsedInValuingPlansDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureCommitmentsAndContingenciesAdditionalInformationDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureCommitmentsAndContingenciesAdditionalInformationDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureCommitmentsAndContingenciesScheduleOfWarrantsIssuedDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureCommitmentsAndContingenciesScheduleOfWarrantsIssuedDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureSubsequentEventsAdditionalInformationDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureSubsequentEventsAdditionalInformationDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureFairValueMeasurementsSummaryOfAssetsAndLiabilitiesCarriedAtFairValueDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureFairValueMeasurementsSummaryOfAssetsAndLiabilitiesCarriedAtFairValueDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureFairValueMeasurementsAdditionalInformationDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureFairValueMeasurementsAdditionalInformationDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/NotesPayableAdditionalInformationDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#NotesPayableAdditionalInformationDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureStockholdersEquityAdditionalInformationDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureStockholdersEquityAdditionalInformationDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/StockholdersEquityScheduleofStockPurchaseWarrantsDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#StockholdersEquityScheduleofStockPurchaseWarrantsDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureRestructuringAndOtherRelatedChargesAdditionalInformationDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureRestructuringAndOtherRelatedChargesAdditionalInformationDetails" />
  <link:roleRef roleURI="http://electrocore.com/role/Role_DisclosureCloudComputingArrangementAdditionalInformationDetails" xlink:type="simple" xlink:href="ecor-20220630.xsd#Role_DisclosureCloudComputingArrangementAdditionalInformationDetails" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureRestructuringAndOtherRelatedChargesSummaryOfRestructuringAndOtherRelatedChargesDetails">
    <link:loc xlink:type="locator" xlink:href="ecor-20220630.xsd#ecor_RestructuringAndOtherRelatedCharges" xlink:label="ecor_RestructuringAndOtherRelatedCharges" xlink:title="ecor_RestructuringAndOtherRelatedCharges" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SeveranceCosts1" xlink:label="us-gaap_SeveranceCosts1" xlink:title="us-gaap_SeveranceCosts1" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="ecor_RestructuringAndOtherRelatedCharges" xlink:to="us-gaap_SeveranceCosts1" xlink:title="Calculation : ecor_RestructuringAndOtherRelatedCharges to us-gaap_SeveranceCosts1" order="0" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherRestructuringCosts" xlink:label="us-gaap_OtherRestructuringCosts" xlink:title="us-gaap_OtherRestructuringCosts" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="ecor_RestructuringAndOtherRelatedCharges" xlink:to="us-gaap_OtherRestructuringCosts" xlink:title="Calculation : ecor_RestructuringAndOtherRelatedCharges to us-gaap_OtherRestructuringCosts" order="1" weight="1" use="optional" />
  </link:calculationLink>
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_StatementCondensedConsolidatedStatementsOfComprehensiveLossUnaudited">
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest" xlink:label="us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest" xlink:title="us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProfitLoss" xlink:label="us-gaap_ProfitLoss" xlink:title="us-gaap_ProfitLoss" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest" xlink:to="us-gaap_ProfitLoss" xlink:title="Calculation : us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest to us-gaap_ProfitLoss" order="0" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax" xlink:label="us-gaap_OtherComprehensiveIncomeLossNetOfTax" xlink:title="us-gaap_OtherComprehensiveIncomeLossNetOfTax" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest" xlink:to="us-gaap_OtherComprehensiveIncomeLossNetOfTax" xlink:title="Calculation : us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest to us-gaap_OtherComprehensiveIncomeLossNetOfTax" order="1" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax" xlink:label="us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax" xlink:title="us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_OtherComprehensiveIncomeLossNetOfTax" xlink:to="us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax" xlink:title="Calculation : us-gaap_OtherComprehensiveIncomeLossNetOfTax to us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax" order="0" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:label="us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:title="us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_OtherComprehensiveIncomeLossNetOfTax" xlink:to="us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:title="Calculation : us-gaap_OtherComprehensiveIncomeLossNetOfTax to us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" order="1" weight="1" use="optional" />
  </link:calculationLink>
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/InventoriesInventoriesDetails">
    <link:loc xlink:type="locator" xlink:href="ecor-20220630.xsd#ecor_InventoryCurrentAndNoncurrent" xlink:label="ecor_InventoryCurrentAndNoncurrent" xlink:title="ecor_InventoryCurrentAndNoncurrent" />
    <link:loc xlink:type="locator" xlink:href="ecor-20220630.xsd#ecor_InventoryRawMaterialsCurrentAndNoncurrent" xlink:label="ecor_InventoryRawMaterialsCurrentAndNoncurrent" xlink:title="ecor_InventoryRawMaterialsCurrentAndNoncurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="ecor_InventoryCurrentAndNoncurrent" xlink:to="ecor_InventoryRawMaterialsCurrentAndNoncurrent" xlink:title="Calculation : ecor_InventoryCurrentAndNoncurrent to ecor_InventoryRawMaterialsCurrentAndNoncurrent" order="0" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="ecor-20220630.xsd#ecor_InventoryWorkInProcessCurrentAndNoncurrent" xlink:label="ecor_InventoryWorkInProcessCurrentAndNoncurrent" xlink:title="ecor_InventoryWorkInProcessCurrentAndNoncurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="ecor_InventoryCurrentAndNoncurrent" xlink:to="ecor_InventoryWorkInProcessCurrentAndNoncurrent" xlink:title="Calculation : ecor_InventoryCurrentAndNoncurrent to ecor_InventoryWorkInProcessCurrentAndNoncurrent" order="1" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="ecor-20220630.xsd#ecor_InventoryFinishedGoodsCurrentAndNoncurrent" xlink:label="ecor_InventoryFinishedGoodsCurrentAndNoncurrent" xlink:title="ecor_InventoryFinishedGoodsCurrentAndNoncurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="ecor_InventoryCurrentAndNoncurrent" xlink:to="ecor_InventoryFinishedGoodsCurrentAndNoncurrent" xlink:title="Calculation : ecor_InventoryCurrentAndNoncurrent to ecor_InventoryFinishedGoodsCurrentAndNoncurrent" order="2" weight="1" use="optional" />
  </link:calculationLink>
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/CondensedConsolidatedBalanceSheetsUnaudited">
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="us-gaap_LiabilitiesAndStockholdersEquity" xlink:title="us-gaap_LiabilitiesAndStockholdersEquity" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Liabilities" xlink:label="us-gaap_Liabilities" xlink:title="us-gaap_Liabilities" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesAndStockholdersEquity" xlink:to="us-gaap_Liabilities" xlink:title="Calculation : us-gaap_LiabilitiesAndStockholdersEquity to us-gaap_Liabilities" order="0" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrent" xlink:label="us-gaap_LiabilitiesCurrent" xlink:title="us-gaap_LiabilitiesCurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_Liabilities" xlink:to="us-gaap_LiabilitiesCurrent" xlink:title="Calculation : us-gaap_Liabilities to us-gaap_LiabilitiesCurrent" order="0" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsPayableCurrent" xlink:label="us-gaap_AccountsPayableCurrent" xlink:title="us-gaap_AccountsPayableCurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesCurrent" xlink:to="us-gaap_AccountsPayableCurrent" xlink:title="Calculation : us-gaap_LiabilitiesCurrent to us-gaap_AccountsPayableCurrent" order="0" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedLiabilitiesCurrent" xlink:label="us-gaap_AccruedLiabilitiesCurrent" xlink:title="us-gaap_AccruedLiabilitiesCurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesCurrent" xlink:to="us-gaap_AccruedLiabilitiesCurrent" xlink:title="Calculation : us-gaap_LiabilitiesCurrent to us-gaap_AccruedLiabilitiesCurrent" order="1" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityCurrent" xlink:label="us-gaap_OperatingLeaseLiabilityCurrent" xlink:title="us-gaap_OperatingLeaseLiabilityCurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesCurrent" xlink:to="us-gaap_OperatingLeaseLiabilityCurrent" xlink:title="Calculation : us-gaap_LiabilitiesCurrent to us-gaap_OperatingLeaseLiabilityCurrent" order="2" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent" xlink:label="us-gaap_OperatingLeaseLiabilityNoncurrent" xlink:title="us-gaap_OperatingLeaseLiabilityNoncurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_Liabilities" xlink:to="us-gaap_OperatingLeaseLiabilityNoncurrent" xlink:title="Calculation : us-gaap_Liabilities to us-gaap_OperatingLeaseLiabilityNoncurrent" order="1" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingencies" xlink:label="us-gaap_CommitmentsAndContingencies" xlink:title="us-gaap_CommitmentsAndContingencies" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesAndStockholdersEquity" xlink:to="us-gaap_CommitmentsAndContingencies" xlink:title="Calculation : us-gaap_LiabilitiesAndStockholdersEquity to us-gaap_CommitmentsAndContingencies" order="1" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity" xlink:label="us-gaap_StockholdersEquity" xlink:title="us-gaap_StockholdersEquity" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesAndStockholdersEquity" xlink:to="us-gaap_StockholdersEquity" xlink:title="Calculation : us-gaap_LiabilitiesAndStockholdersEquity to us-gaap_StockholdersEquity" order="2" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockValueOutstanding" xlink:label="us-gaap_PreferredStockValueOutstanding" xlink:title="us-gaap_PreferredStockValueOutstanding" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_StockholdersEquity" xlink:to="us-gaap_PreferredStockValueOutstanding" xlink:title="Calculation : us-gaap_StockholdersEquity to us-gaap_PreferredStockValueOutstanding" order="0" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockValueOutstanding" xlink:label="us-gaap_CommonStockValueOutstanding" xlink:title="us-gaap_CommonStockValueOutstanding" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_StockholdersEquity" xlink:to="us-gaap_CommonStockValueOutstanding" xlink:title="Calculation : us-gaap_StockholdersEquity to us-gaap_CommonStockValueOutstanding" order="1" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapitalCommonStock" xlink:label="us-gaap_AdditionalPaidInCapitalCommonStock" xlink:title="us-gaap_AdditionalPaidInCapitalCommonStock" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_StockholdersEquity" xlink:to="us-gaap_AdditionalPaidInCapitalCommonStock" xlink:title="Calculation : us-gaap_StockholdersEquity to us-gaap_AdditionalPaidInCapitalCommonStock" order="2" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="us-gaap_RetainedEarningsAccumulatedDeficit" xlink:title="us-gaap_RetainedEarningsAccumulatedDeficit" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_StockholdersEquity" xlink:to="us-gaap_RetainedEarningsAccumulatedDeficit" xlink:title="Calculation : us-gaap_StockholdersEquity to us-gaap_RetainedEarningsAccumulatedDeficit" order="3" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:title="us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_StockholdersEquity" xlink:to="us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:title="Calculation : us-gaap_StockholdersEquity to us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" order="4" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Assets" xlink:label="us-gaap_Assets" xlink:title="us-gaap_Assets" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsCurrent" xlink:label="us-gaap_AssetsCurrent" xlink:title="us-gaap_AssetsCurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_Assets" xlink:to="us-gaap_AssetsCurrent" xlink:title="Calculation : us-gaap_Assets to us-gaap_AssetsCurrent" order="0" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:title="us-gaap_CashAndCashEquivalentsAtCarryingValue" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_AssetsCurrent" xlink:to="us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:title="Calculation : us-gaap_AssetsCurrent to us-gaap_CashAndCashEquivalentsAtCarryingValue" order="0" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCashCurrent" xlink:label="us-gaap_RestrictedCashCurrent" xlink:title="us-gaap_RestrictedCashCurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_AssetsCurrent" xlink:to="us-gaap_RestrictedCashCurrent" xlink:title="Calculation : us-gaap_AssetsCurrent to us-gaap_RestrictedCashCurrent" order="1" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsReceivableNetCurrent" xlink:label="us-gaap_AccountsReceivableNetCurrent" xlink:title="us-gaap_AccountsReceivableNetCurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_AssetsCurrent" xlink:to="us-gaap_AccountsReceivableNetCurrent" xlink:title="Calculation : us-gaap_AssetsCurrent to us-gaap_AccountsReceivableNetCurrent" order="2" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryNet" xlink:label="us-gaap_InventoryNet" xlink:title="us-gaap_InventoryNet" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_AssetsCurrent" xlink:to="us-gaap_InventoryNet" xlink:title="Calculation : us-gaap_AssetsCurrent to us-gaap_InventoryNet" order="3" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent" xlink:label="us-gaap_PrepaidExpenseAndOtherAssetsCurrent" xlink:title="us-gaap_PrepaidExpenseAndOtherAssetsCurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_AssetsCurrent" xlink:to="us-gaap_PrepaidExpenseAndOtherAssetsCurrent" xlink:title="Calculation : us-gaap_AssetsCurrent to us-gaap_PrepaidExpenseAndOtherAssetsCurrent" order="4" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryNoncurrent" xlink:label="us-gaap_InventoryNoncurrent" xlink:title="us-gaap_InventoryNoncurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_Assets" xlink:to="us-gaap_InventoryNoncurrent" xlink:title="Calculation : us-gaap_Assets to us-gaap_InventoryNoncurrent" order="1" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="us-gaap_PropertyPlantAndEquipmentNet" xlink:title="us-gaap_PropertyPlantAndEquipmentNet" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_Assets" xlink:to="us-gaap_PropertyPlantAndEquipmentNet" xlink:title="Calculation : us-gaap_Assets to us-gaap_PropertyPlantAndEquipmentNet" order="2" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseRightOfUseAsset" xlink:label="us-gaap_OperatingLeaseRightOfUseAsset" xlink:title="us-gaap_OperatingLeaseRightOfUseAsset" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_Assets" xlink:to="us-gaap_OperatingLeaseRightOfUseAsset" xlink:title="Calculation : us-gaap_Assets to us-gaap_OperatingLeaseRightOfUseAsset" order="3" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAssetsNoncurrent" xlink:label="us-gaap_OtherAssetsNoncurrent" xlink:title="us-gaap_OtherAssetsNoncurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_Assets" xlink:to="us-gaap_OtherAssetsNoncurrent" xlink:title="Calculation : us-gaap_Assets to us-gaap_OtherAssetsNoncurrent" order="4" weight="1" use="optional" />
  </link:calculationLink>
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureLeasesFutureMinimumLeasePaymentsUnderNonCancellableOperatingLeasesDetails">
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue" xlink:label="us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue" xlink:title="us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths" xlink:label="us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths" xlink:title="us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue" xlink:to="us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths" xlink:title="Calculation : us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue to us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths" order="0" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo" xlink:label="us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo" xlink:title="us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue" xlink:to="us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo" xlink:title="Calculation : us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue to us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo" order="1" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree" xlink:label="us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree" xlink:title="us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue" xlink:to="us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree" xlink:title="Calculation : us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue to us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree" order="2" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour" xlink:label="us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour" xlink:title="us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue" xlink:to="us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour" xlink:title="Calculation : us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue to us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour" order="3" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive" xlink:label="us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive" xlink:title="us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue" xlink:to="us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive" xlink:title="Calculation : us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue to us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive" order="4" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive" xlink:label="us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive" xlink:title="us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue" xlink:to="us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive" xlink:title="Calculation : us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue to us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive" order="5" weight="1" use="optional" />
  </link:calculationLink>
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_StatementCondensedConsolidatedStatementsOfCashFlowsUnaudited">
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:label="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:title="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:title="us-gaap_NetCashProvidedByUsedInOperatingActivities" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:to="us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:title="Calculation : us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect to us-gaap_NetCashProvidedByUsedInOperatingActivities" order="0" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProfitLoss" xlink:label="us-gaap_ProfitLoss" xlink:title="us-gaap_ProfitLoss" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:to="us-gaap_ProfitLoss" xlink:title="Calculation : us-gaap_NetCashProvidedByUsedInOperatingActivities to us-gaap_ProfitLoss" order="0" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensation" xlink:label="us-gaap_ShareBasedCompensation" xlink:title="us-gaap_ShareBasedCompensation" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:to="us-gaap_ShareBasedCompensation" xlink:title="Calculation : us-gaap_NetCashProvidedByUsedInOperatingActivities to us-gaap_ShareBasedCompensation" order="1" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DepreciationDepletionAndAmortization" xlink:label="us-gaap_DepreciationDepletionAndAmortization" xlink:title="us-gaap_DepreciationDepletionAndAmortization" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:to="us-gaap_DepreciationDepletionAndAmortization" xlink:title="Calculation : us-gaap_NetCashProvidedByUsedInOperatingActivities to us-gaap_DepreciationDepletionAndAmortization" order="2" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments" xlink:label="us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments" xlink:title="us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:to="us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments" xlink:title="Calculation : us-gaap_NetCashProvidedByUsedInOperatingActivities to us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments" order="3" weight="-1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="ecor-20220630.xsd#ecor_IncreaseDecreaseInRightOfUseOperatingLeases" xlink:label="ecor_IncreaseDecreaseInRightOfUseOperatingLeases" xlink:title="ecor_IncreaseDecreaseInRightOfUseOperatingLeases" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:to="ecor_IncreaseDecreaseInRightOfUseOperatingLeases" xlink:title="Calculation : us-gaap_NetCashProvidedByUsedInOperatingActivities to ecor_IncreaseDecreaseInRightOfUseOperatingLeases" order="4" weight="-1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:title="us-gaap_GainsLossesOnExtinguishmentOfDebt" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:to="us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:title="Calculation : us-gaap_NetCashProvidedByUsedInOperatingActivities to us-gaap_GainsLossesOnExtinguishmentOfDebt" order="5" weight="-1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="ecor-20220630.xsd#ecor_NetNoncashLeaseExpense" xlink:label="ecor_NetNoncashLeaseExpense" xlink:title="ecor_NetNoncashLeaseExpense" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:to="ecor_NetNoncashLeaseExpense" xlink:title="Calculation : us-gaap_NetCashProvidedByUsedInOperatingActivities to ecor_NetNoncashLeaseExpense" order="6" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryWriteDown" xlink:label="us-gaap_InventoryWriteDown" xlink:title="us-gaap_InventoryWriteDown" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:to="us-gaap_InventoryWriteDown" xlink:title="Calculation : us-gaap_NetCashProvidedByUsedInOperatingActivities to us-gaap_InventoryWriteDown" order="7" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:label="us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:title="us-gaap_IncreaseDecreaseInAccountsReceivable" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:to="us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:title="Calculation : us-gaap_NetCashProvidedByUsedInOperatingActivities to us-gaap_IncreaseDecreaseInAccountsReceivable" order="8" weight="-1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInInventories" xlink:label="us-gaap_IncreaseDecreaseInInventories" xlink:title="us-gaap_IncreaseDecreaseInInventories" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:to="us-gaap_IncreaseDecreaseInInventories" xlink:title="Calculation : us-gaap_NetCashProvidedByUsedInOperatingActivities to us-gaap_IncreaseDecreaseInInventories" order="9" weight="-1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" xlink:label="us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" xlink:title="us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:to="us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" xlink:title="Calculation : us-gaap_NetCashProvidedByUsedInOperatingActivities to us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" order="10" weight="-1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccountsPayable" xlink:label="us-gaap_IncreaseDecreaseInAccountsPayable" xlink:title="us-gaap_IncreaseDecreaseInAccountsPayable" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:to="us-gaap_IncreaseDecreaseInAccountsPayable" xlink:title="Calculation : us-gaap_NetCashProvidedByUsedInOperatingActivities to us-gaap_IncreaseDecreaseInAccountsPayable" order="11" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities" xlink:label="us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities" xlink:title="us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:to="us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities" xlink:title="Calculation : us-gaap_NetCashProvidedByUsedInOperatingActivities to us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities" order="12" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOperatingLeaseLiability" xlink:label="us-gaap_IncreaseDecreaseInOperatingLeaseLiability" xlink:title="us-gaap_IncreaseDecreaseInOperatingLeaseLiability" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:to="us-gaap_IncreaseDecreaseInOperatingLeaseLiability" xlink:title="Calculation : us-gaap_NetCashProvidedByUsedInOperatingActivities to us-gaap_IncreaseDecreaseInOperatingLeaseLiability" order="13" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets" xlink:label="us-gaap_IncreaseDecreaseInOtherOperatingAssets" xlink:title="us-gaap_IncreaseDecreaseInOtherOperatingAssets" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:to="us-gaap_IncreaseDecreaseInOtherOperatingAssets" xlink:title="Calculation : us-gaap_NetCashProvidedByUsedInOperatingActivities to us-gaap_IncreaseDecreaseInOtherOperatingAssets" order="14" weight="-1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:title="us-gaap_NetCashProvidedByUsedInInvestingActivities" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:to="us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:title="Calculation : us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect to us-gaap_NetCashProvidedByUsedInInvestingActivities" order="1" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireMarketableSecurities" xlink:label="us-gaap_PaymentsToAcquireMarketableSecurities" xlink:title="us-gaap_PaymentsToAcquireMarketableSecurities" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:to="us-gaap_PaymentsToAcquireMarketableSecurities" xlink:title="Calculation : us-gaap_NetCashProvidedByUsedInInvestingActivities to us-gaap_PaymentsToAcquireMarketableSecurities" order="0" weight="-1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities" xlink:label="us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities" xlink:title="us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:to="us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities" xlink:title="Calculation : us-gaap_NetCashProvidedByUsedInInvestingActivities to us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities" order="1" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:title="us-gaap_NetCashProvidedByUsedInFinancingActivities" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:to="us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:title="Calculation : us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect to us-gaap_NetCashProvidedByUsedInFinancingActivities" order="2" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="ecor-20220630.xsd#ecor_SharesIssuedNetOfRelatedExpenses" xlink:label="ecor_SharesIssuedNetOfRelatedExpenses" xlink:title="ecor_SharesIssuedNetOfRelatedExpenses" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:to="ecor_SharesIssuedNetOfRelatedExpenses" xlink:title="Calculation : us-gaap_NetCashProvidedByUsedInFinancingActivities to ecor_SharesIssuedNetOfRelatedExpenses" order="0" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations" xlink:label="us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations" xlink:title="us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:to="us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations" xlink:title="Calculation : us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect to us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations" order="3" weight="1" use="optional" />
  </link:calculationLink>
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureCashCashEquivalentsAndMarketableSecuritiesSummaryOfCashCashEquivalentsAndMarketableSecuritiesDetails">
    <link:loc xlink:type="locator" xlink:href="ecor-20220630.xsd#ecor_CashAndCashEquivalentsAndMarketableSecuritiesAmortizedCostBasisCurrent" xlink:label="ecor_CashAndCashEquivalentsAndMarketableSecuritiesAmortizedCostBasisCurrent" xlink:title="ecor_CashAndCashEquivalentsAndMarketableSecuritiesAmortizedCostBasisCurrent" />
    <link:loc xlink:type="locator" xlink:href="ecor-20220630.xsd#ecor_CashAndCashEquivalentsAndMarketableSecuritiesAccumulatedGrossUnrealizedGainsBeforeTaxCurrent" xlink:label="ecor_CashAndCashEquivalentsAndMarketableSecuritiesAccumulatedGrossUnrealizedGainsBeforeTaxCurrent" xlink:title="ecor_CashAndCashEquivalentsAndMarketableSecuritiesAccumulatedGrossUnrealizedGainsBeforeTaxCurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="ecor_CashAndCashEquivalentsAndMarketableSecuritiesAmortizedCostBasisCurrent" xlink:to="ecor_CashAndCashEquivalentsAndMarketableSecuritiesAccumulatedGrossUnrealizedGainsBeforeTaxCurrent" xlink:title="Calculation : ecor_CashAndCashEquivalentsAndMarketableSecuritiesAmortizedCostBasisCurrent to ecor_CashAndCashEquivalentsAndMarketableSecuritiesAccumulatedGrossUnrealizedGainsBeforeTaxCurrent" order="0" weight="-1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="ecor-20220630.xsd#ecor_CashAndCashEquivalentsAndMarketableSecuritiesAccumulatedGrossUnrealizedLossBeforeTaxCurrent" xlink:label="ecor_CashAndCashEquivalentsAndMarketableSecuritiesAccumulatedGrossUnrealizedLossBeforeTaxCurrent" xlink:title="ecor_CashAndCashEquivalentsAndMarketableSecuritiesAccumulatedGrossUnrealizedLossBeforeTaxCurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="ecor_CashAndCashEquivalentsAndMarketableSecuritiesAmortizedCostBasisCurrent" xlink:to="ecor_CashAndCashEquivalentsAndMarketableSecuritiesAccumulatedGrossUnrealizedLossBeforeTaxCurrent" xlink:title="Calculation : ecor_CashAndCashEquivalentsAndMarketableSecuritiesAmortizedCostBasisCurrent to ecor_CashAndCashEquivalentsAndMarketableSecuritiesAccumulatedGrossUnrealizedLossBeforeTaxCurrent" order="1" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsAndShortTermInvestments" xlink:label="us-gaap_CashCashEquivalentsAndShortTermInvestments" xlink:title="us-gaap_CashCashEquivalentsAndShortTermInvestments" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="ecor_CashAndCashEquivalentsAndMarketableSecuritiesAmortizedCostBasisCurrent" xlink:to="us-gaap_CashCashEquivalentsAndShortTermInvestments" xlink:title="Calculation : ecor_CashAndCashEquivalentsAndMarketableSecuritiesAmortizedCostBasisCurrent to us-gaap_CashCashEquivalentsAndShortTermInvestments" order="2" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis" xlink:label="us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis" xlink:title="us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" xlink:label="us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" xlink:title="us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis" xlink:to="us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" xlink:title="Calculation : us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis to us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" order="0" weight="-1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" xlink:label="us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" xlink:title="us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis" xlink:to="us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" xlink:title="Calculation : us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis to us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" order="1" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent" xlink:title="us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis" xlink:to="us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent" xlink:title="Calculation : us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis to us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent" order="2" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="ecor-20220630.xsd#ecor_CashAndCashEquivalentsAmortizedCost" xlink:label="ecor_CashAndCashEquivalentsAmortizedCost" xlink:title="ecor_CashAndCashEquivalentsAmortizedCost" />
    <link:loc xlink:type="locator" xlink:href="ecor-20220630.xsd#ecor_CashAndCashEquivalentsAccumulatedGrossUnrealizedGainBeforeTax" xlink:label="ecor_CashAndCashEquivalentsAccumulatedGrossUnrealizedGainBeforeTax" xlink:title="ecor_CashAndCashEquivalentsAccumulatedGrossUnrealizedGainBeforeTax" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="ecor_CashAndCashEquivalentsAmortizedCost" xlink:to="ecor_CashAndCashEquivalentsAccumulatedGrossUnrealizedGainBeforeTax" xlink:title="Calculation : ecor_CashAndCashEquivalentsAmortizedCost to ecor_CashAndCashEquivalentsAccumulatedGrossUnrealizedGainBeforeTax" order="0" weight="-1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="ecor-20220630.xsd#ecor_CashAndCashEquivalentsAccumulatedGrossUnrealizedLossBeforeTax" xlink:label="ecor_CashAndCashEquivalentsAccumulatedGrossUnrealizedLossBeforeTax" xlink:title="ecor_CashAndCashEquivalentsAccumulatedGrossUnrealizedLossBeforeTax" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="ecor_CashAndCashEquivalentsAmortizedCost" xlink:to="ecor_CashAndCashEquivalentsAccumulatedGrossUnrealizedLossBeforeTax" xlink:title="Calculation : ecor_CashAndCashEquivalentsAmortizedCost to ecor_CashAndCashEquivalentsAccumulatedGrossUnrealizedLossBeforeTax" order="1" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:title="us-gaap_CashAndCashEquivalentsAtCarryingValue" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="ecor_CashAndCashEquivalentsAmortizedCost" xlink:to="us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:title="Calculation : ecor_CashAndCashEquivalentsAmortizedCost to us-gaap_CashAndCashEquivalentsAtCarryingValue" order="2" weight="1" use="optional" />
  </link:calculationLink>
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureLeasesSupplementalBalanceSheetInformationForOperatingLeasesDetails">
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiability" xlink:label="us-gaap_OperatingLeaseLiability" xlink:title="us-gaap_OperatingLeaseLiability" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityCurrent" xlink:label="us-gaap_OperatingLeaseLiabilityCurrent" xlink:title="us-gaap_OperatingLeaseLiabilityCurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_OperatingLeaseLiability" xlink:to="us-gaap_OperatingLeaseLiabilityCurrent" xlink:title="Calculation : us-gaap_OperatingLeaseLiability to us-gaap_OperatingLeaseLiabilityCurrent" order="0" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent" xlink:label="us-gaap_OperatingLeaseLiabilityNoncurrent" xlink:title="us-gaap_OperatingLeaseLiabilityNoncurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_OperatingLeaseLiability" xlink:to="us-gaap_OperatingLeaseLiabilityNoncurrent" xlink:title="Calculation : us-gaap_OperatingLeaseLiability to us-gaap_OperatingLeaseLiabilityNoncurrent" order="1" weight="1" use="optional" />
  </link:calculationLink>
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_StatementCondensedConsolidatedStatementsOfOperationsUnaudited">
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProfitLoss" xlink:label="us-gaap_ProfitLoss" xlink:title="us-gaap_ProfitLoss" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xlink:label="us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xlink:title="us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_ProfitLoss" xlink:to="us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xlink:title="Calculation : us-gaap_ProfitLoss to us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" order="0" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingIncomeLoss" xlink:label="us-gaap_OperatingIncomeLoss" xlink:title="us-gaap_OperatingIncomeLoss" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xlink:to="us-gaap_OperatingIncomeLoss" xlink:title="Calculation : us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest to us-gaap_OperatingIncomeLoss" order="0" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GrossProfit" xlink:label="us-gaap_GrossProfit" xlink:title="us-gaap_GrossProfit" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_OperatingIncomeLoss" xlink:to="us-gaap_GrossProfit" xlink:title="Calculation : us-gaap_OperatingIncomeLoss to us-gaap_GrossProfit" order="0" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax" xlink:label="us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax" xlink:title="us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_GrossProfit" xlink:to="us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax" xlink:title="Calculation : us-gaap_GrossProfit to us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax" order="0" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostOfGoodsAndServicesSold" xlink:label="us-gaap_CostOfGoodsAndServicesSold" xlink:title="us-gaap_CostOfGoodsAndServicesSold" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_GrossProfit" xlink:to="us-gaap_CostOfGoodsAndServicesSold" xlink:title="Calculation : us-gaap_GrossProfit to us-gaap_CostOfGoodsAndServicesSold" order="1" weight="-1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingExpenses" xlink:label="us-gaap_OperatingExpenses" xlink:title="us-gaap_OperatingExpenses" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_OperatingIncomeLoss" xlink:to="us-gaap_OperatingExpenses" xlink:title="Calculation : us-gaap_OperatingIncomeLoss to us-gaap_OperatingExpenses" order="1" weight="-1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpense" xlink:label="us-gaap_ResearchAndDevelopmentExpense" xlink:title="us-gaap_ResearchAndDevelopmentExpense" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_OperatingExpenses" xlink:to="us-gaap_ResearchAndDevelopmentExpense" xlink:title="Calculation : us-gaap_OperatingExpenses to us-gaap_ResearchAndDevelopmentExpense" order="0" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SellingGeneralAndAdministrativeExpense" xlink:label="us-gaap_SellingGeneralAndAdministrativeExpense" xlink:title="us-gaap_SellingGeneralAndAdministrativeExpense" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_OperatingExpenses" xlink:to="us-gaap_SellingGeneralAndAdministrativeExpense" xlink:title="Calculation : us-gaap_OperatingExpenses to us-gaap_SellingGeneralAndAdministrativeExpense" order="1" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NonoperatingIncomeExpense" xlink:label="us-gaap_NonoperatingIncomeExpense" xlink:title="us-gaap_NonoperatingIncomeExpense" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xlink:to="us-gaap_NonoperatingIncomeExpense" xlink:title="Calculation : us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest to us-gaap_NonoperatingIncomeExpense" order="1" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestAndOtherIncome" xlink:label="us-gaap_InterestAndOtherIncome" xlink:title="us-gaap_InterestAndOtherIncome" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NonoperatingIncomeExpense" xlink:to="us-gaap_InterestAndOtherIncome" xlink:title="Calculation : us-gaap_NonoperatingIncomeExpense to us-gaap_InterestAndOtherIncome" order="0" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherNonoperatingExpense" xlink:label="us-gaap_OtherNonoperatingExpense" xlink:title="us-gaap_OtherNonoperatingExpense" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NonoperatingIncomeExpense" xlink:to="us-gaap_OtherNonoperatingExpense" xlink:title="Calculation : us-gaap_NonoperatingIncomeExpense to us-gaap_OtherNonoperatingExpense" order="1" weight="-1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:title="us-gaap_GainsLossesOnExtinguishmentOfDebt" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NonoperatingIncomeExpense" xlink:to="us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:title="Calculation : us-gaap_NonoperatingIncomeExpense to us-gaap_GainsLossesOnExtinguishmentOfDebt" order="2" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="us-gaap_IncomeTaxExpenseBenefit" xlink:title="us-gaap_IncomeTaxExpenseBenefit" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_ProfitLoss" xlink:to="us-gaap_IncomeTaxExpenseBenefit" xlink:title="Calculation : us-gaap_ProfitLoss to us-gaap_IncomeTaxExpenseBenefit" order="1" weight="-1" use="optional" />
  </link:calculationLink>
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureAccruedExpensesAndOtherCurrentLiabilitiesScheduleOfAccruedExpensesDetails">
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedLiabilitiesCurrent" xlink:label="us-gaap_AccruedLiabilitiesCurrent" xlink:title="us-gaap_AccruedLiabilitiesCurrent" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedProfessionalFeesCurrent" xlink:label="us-gaap_AccruedProfessionalFeesCurrent" xlink:title="us-gaap_AccruedProfessionalFeesCurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_AccruedLiabilitiesCurrent" xlink:to="us-gaap_AccruedProfessionalFeesCurrent" xlink:title="Calculation : us-gaap_AccruedLiabilitiesCurrent to us-gaap_AccruedProfessionalFeesCurrent" order="0" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedBonusesCurrent" xlink:label="us-gaap_AccruedBonusesCurrent" xlink:title="us-gaap_AccruedBonusesCurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_AccruedLiabilitiesCurrent" xlink:to="us-gaap_AccruedBonusesCurrent" xlink:title="Calculation : us-gaap_AccruedLiabilitiesCurrent to us-gaap_AccruedBonusesCurrent" order="1" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="ecor-20220630.xsd#ecor_AccruedLegalFeesLitigationExpense" xlink:label="ecor_AccruedLegalFeesLitigationExpense" xlink:title="ecor_AccruedLegalFeesLitigationExpense" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_AccruedLiabilitiesCurrent" xlink:to="ecor_AccruedLegalFeesLitigationExpense" xlink:title="Calculation : us-gaap_AccruedLiabilitiesCurrent to ecor_AccruedLegalFeesLitigationExpense" order="2" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherEmployeeRelatedLiabilitiesCurrent" xlink:label="us-gaap_OtherEmployeeRelatedLiabilitiesCurrent" xlink:title="us-gaap_OtherEmployeeRelatedLiabilitiesCurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_AccruedLiabilitiesCurrent" xlink:to="us-gaap_OtherEmployeeRelatedLiabilitiesCurrent" xlink:title="Calculation : us-gaap_AccruedLiabilitiesCurrent to us-gaap_OtherEmployeeRelatedLiabilitiesCurrent" order="3" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedIncomeTaxesCurrent" xlink:label="us-gaap_AccruedIncomeTaxesCurrent" xlink:title="us-gaap_AccruedIncomeTaxesCurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_AccruedLiabilitiesCurrent" xlink:to="us-gaap_AccruedIncomeTaxesCurrent" xlink:title="Calculation : us-gaap_AccruedLiabilitiesCurrent to us-gaap_AccruedIncomeTaxesCurrent" order="4" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SettlementLiabilitiesCurrent" xlink:label="us-gaap_SettlementLiabilitiesCurrent" xlink:title="us-gaap_SettlementLiabilitiesCurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_AccruedLiabilitiesCurrent" xlink:to="us-gaap_SettlementLiabilitiesCurrent" xlink:title="Calculation : us-gaap_AccruedLiabilitiesCurrent to us-gaap_SettlementLiabilitiesCurrent" order="5" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAccruedLiabilitiesCurrent" xlink:label="us-gaap_OtherAccruedLiabilitiesCurrent" xlink:title="us-gaap_OtherAccruedLiabilitiesCurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_AccruedLiabilitiesCurrent" xlink:to="us-gaap_OtherAccruedLiabilitiesCurrent" xlink:title="Calculation : us-gaap_AccruedLiabilitiesCurrent to us-gaap_OtherAccruedLiabilitiesCurrent" order="6" weight="1" use="optional" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedInsuranceCurrentAndNoncurrent" xlink:label="us-gaap_AccruedInsuranceCurrentAndNoncurrent" xlink:title="us-gaap_AccruedInsuranceCurrentAndNoncurrent" />
    <link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_AccruedLiabilitiesCurrent" xlink:to="us-gaap_AccruedInsuranceCurrentAndNoncurrent" xlink:title="Calculation : us-gaap_AccruedLiabilitiesCurrent to us-gaap_AccruedInsuranceCurrentAndNoncurrent" order="7" weight="1" use="optional" />
  </link:calculationLink>
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DocumentDocumentAndEntityInformation" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/CondensedConsolidatedBalanceSheetsUnauditedParenthetical" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/CondensedConsolidatedStatementsofEquity" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureTheCompany" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureSummaryOfSignificantAccountingPolicies" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/SignificantRisksandUncertainties" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Revenue" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureInventories" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureLeases" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureAccruedExpensesAndOtherCurrentLiabilities" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureNetLossPerShare" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Incometaxes" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureStockBasedCompensation" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureCommitmentsAndContingencies" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureSubsequentEvents" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureSummaryOfSignificantAccountingPoliciesPolicies" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/SummaryofSignificantAccountingPoliciesTables" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/SignificantRisksandUncertaintiesTables" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/RevenueTables" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureInventoriesTables" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureLeasesTables" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureAccruedExpensesAndOtherCurrentLiabilitiesTables" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureNetLossPerShareTables" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureStockBasedCompensationTables" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/TheCompanyDetails" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/SummaryofSignificantAccountingPoliciesDetails" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/SummaryofSignificantAccountingPoliciesScheduleofcashequivalentsandrestrictedcashDetails" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/SignificantRisksandUncertaintiesAdditionalInformationDetails" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/SignificantRisksandUncertaintiesScheduleofcompanysnetsalesDetails" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/SignificantRisksandUncertaintiesScheduleoffurtherrevenueconcentrationwithintheVADoDDetails" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/RevenueSummaryofNetSalesDisaggregatedbyGeographicAreaDetails" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/RevenueAdditionalInformationDetails" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/InventoriesAdditionalInformationDetails" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureLeasesSupplementalStatementOfCashFlowsInformationForOperatingLeasesDetails" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureLeasesFutureMinimumLeasePaymentsUnderNonCancellableOperatingLeasesDetails2" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureLeasesAdditionalInformationDetails" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/AccruedExpensesandOtherCurrentLiabilitiesDetails" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/NetLossPerShareAdditionalInformationDetails" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureNetLossPerShareScheduleOfCommonStockEquivalentsExcludedFromComputationOfDilutedLossPerShareDetails" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/NetLossPerShareScheduleofstockpurchasewarrantsoutstandingDetails2" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureIncomeTaxesAdditionalInformationDetails" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureStockBasedCompensationAdditionalInformationDetails" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureStockBasedCompensationSummaryOfActivityRelatedToStockOptionsDetails" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureStockBasedCompensationSummaryOfActivityRelatedToRestrictedStockAwardsGrantedDetails" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureStockBasedCompensationSummaryOfActivityRelatedToRestrictedStockAndDeferredStockUnitsGrantedDetails" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureStockBasedCompensationScheduleOfRecognizedStockCompensationForEquityAwardsDetails" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureStockBasedCompensationSummaryOfWeightedAverageAssumptionsUsedInValuingPlansDetails" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureCommitmentsAndContingenciesAdditionalInformationDetails" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureCommitmentsAndContingenciesScheduleOfWarrantsIssuedDetails" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureSubsequentEventsAdditionalInformationDetails" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureFairValueMeasurementsSummaryOfAssetsAndLiabilitiesCarriedAtFairValueDetails" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureFairValueMeasurementsAdditionalInformationDetails" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/NotesPayableAdditionalInformationDetails" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureStockholdersEquityAdditionalInformationDetails" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/StockholdersEquityScheduleofStockPurchaseWarrantsDetails" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureRestructuringAndOtherRelatedChargesAdditionalInformationDetails" />
  <link:calculationLink xlink:type="extended" xlink:role="http://electrocore.com/role/Role_DisclosureCloudComputingArrangementAdditionalInformationDetails" />
</link:linkbase>
